Hull welcome back Loma Kivalu to bolster the forwards and are hopeful that Simon Humberstone may be fit to return to his pivotal position at off half.
Hull played well last week and could have taken something from the game but they let a couple of scoring chances pass them by which proved costly.
Hull, having moved up to National 2 North, have seen there is less room for error.
Caldy will be another tough game and as league leaders will arrive full of confidence. Last week, they ran in 61 points against Luctonians and clearly have a dangerous attack.
Hull have shown unity of purpose and have battled hard to take points from three of their first five games.
They will need to defend with their usual commitment and be tactically aware as they go in search of more points against a good Caldy side who have tasted life in a higher division.
Hull have attacking threats of their own and will be looking to impose their game on their opponents from over the Pennines and get something from this encounter.